Loss of function in mitochondria, the key organelle responsible for cellular energy production, can result in the excess fatigue and other symptoms that are common complaints in almost every chronic disease. At the molecular level, a reduction in mitochondrial function occurs as a result of the following changes: (1) a loss of maintenance of the electrical and chemical transmembrane potential of the inner mitochondrial membrane, (2) alterations in the function of the electron transport chain, or (3) a reduction in the transport of critical metabolites into mitochondria. In turn, these changes result in a reduced efficiency of oxidative phosphorylation and a reduction in production of adenosine-5’-triphosphate (ATP).

Several components of this system require routine replacement, and this need can be facilitated with natural supplements. Clinical trials have shown the utility of using oral replacement supplements, such as L-carnitine, alpha-lipoic acid (α-lipoic acid [1,2-dithiolane-3-pentanoic acid]), coenzyme Q10 (CoQ10 [ubiquinone]), reduced nicotinamide adenine dinucleotide (NADH), membrane phospholipids, and other supplements. Combinations of these supplements can reduce significantly the fatigue and other symptoms associated with chronic disease and can naturally restore mitochondrial function, even in long-term patients with intractable fatigue (19).

Metabiolab can monitor the effects of supplementation at the molecular levels that can sustain clinical observations.


Manufacturers of processed foods and agricultural products

We eat food and that food represents an important source of anti-oxidants. Anti-oxidants concentration largely varies in strain of vegetable, fruit or any other plant depending on breeding, cultivation, harvesting, post-harvest storage and processing conditions. Thus quality control during food manufacturing and processing is mandatory and requires a close monitoring of the anti-oxidant status.

Metabiolab provides the advanced analytical techniques to assess the anti-oxidant content of plant products as well as processed food products.

Manufacturers of pet foods

As for humans, anti-oxidant status may be important for animals. In pet foods, nutritional formulation often includes enhanced levels of anti-oxidants to avoid pets inflammatory diseases.
Oxidative stress is also responsible for food allergy and intolerance that could lead to several skin and stomach problems and cause discomfort and pain to animals. Monitoring the levels of oxidative stress in pets harbouring specific allergies through specific nutritional formulations reducing damages by supplementing appropriate anti-oxidants.